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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SCN1A All Species: 22.73
Human Site: T1088 Identified Species: 50
UniProt: P35498 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P35498 NP_008851.3 2009 228972 T1088 G T T S G I G T G S S V E K Y
Chimpanzee Pan troglodytes XP_515872 2009 228955 T1088 G T T S G I G T G S S V E K Y
Rhesus Macaque Macaca mulatta XP_001101023 2008 228805 T1088 G T T S G I G T G S S V E K Y
Dog Lupus familis XP_535941 2009 228773 T1088 G T T S G I G T G S S V E K Y
Cat Felis silvestris
Mouse Mus musculus Q62205 1984 225794 F1061 E K D K I S G F S S S L D K S
Rat Rattus norvegicus P04774 2009 228752 T1088 G T T S G I G T G S S V E K Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512686 2008 228349 I1081 G N G T T S G I G S S V E K Y
Chicken Gallus gallus XP_001233839 2002 227119 T1085 G T T S G I G T G S S V E K Y
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q2XVR3 1829 207718 F1002 E H D Y F E T F I I F M I L L
Tiger Blowfish Takifugu rubipres Q2XVR7 1892 213080 R1040 F T D N C V K R W P C L N V D
Fruit Fly Dros. melanogaster P35500 2131 239344 E1147 L I K K G I K E Q T Q L E V A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.9 99.6 98.5 N.A. 76.5 98.1 N.A. 88.2 90.6 N.A. 62.3 60.7 44 N.A. N.A. N.A.
Protein Similarity: 100 99.9 99.8 99.4 N.A. 85.9 99.3 N.A. 93.7 94.9 N.A. 74.3 73.6 61.3 N.A. N.A. N.A.
P-Site Identity: 100 100 100 100 N.A. 26.6 100 N.A. 60 100 N.A. 0 6.6 20 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 40 100 N.A. 66.6 100 N.A. 6.6 26.6 33.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % A
% Cys: 0 0 0 0 10 0 0 0 0 0 10 0 0 0 0 % C
% Asp: 0 0 28 0 0 0 0 0 0 0 0 0 10 0 10 % D
% Glu: 19 0 0 0 0 10 0 10 0 0 0 0 73 0 0 % E
% Phe: 10 0 0 0 10 0 0 19 0 0 10 0 0 0 0 % F
% Gly: 64 0 10 0 64 0 73 0 64 0 0 0 0 0 0 % G
% His: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 10 0 0 10 64 0 10 10 10 0 0 10 0 0 % I
% Lys: 0 10 10 19 0 0 19 0 0 0 0 0 0 73 0 % K
% Leu: 10 0 0 0 0 0 0 0 0 0 0 28 0 10 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % M
% Asn: 0 10 0 10 0 0 0 0 0 0 0 0 10 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 10 0 10 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 55 0 19 0 0 10 73 73 0 0 0 10 % S
% Thr: 0 64 55 10 10 0 10 55 0 10 0 0 0 0 0 % T
% Val: 0 0 0 0 0 10 0 0 0 0 0 64 0 19 0 % V
% Trp: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % W
% Tyr: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 64 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _